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Being interested in developmental physiology, her research focuses on how the environment both before we are born and in our early years can influence our life-long health. Dr Poore was appointed Lecturer in Physiology inafter first moving to Southampton in to an active research team. Originating in Australia, Dr Poore completed her PhD in fetal physiology at Monash University in Melbourne, before moving to the UK and spending several years as a post-doctoral researcher at the University of Cambridge.
Alongside her roles teaching and leading modules for the Bachelor of Medicine programmes, she has a keen interest in the Developmental Origins of Health and Disease DOHaD research field, in particular how the early nutritional environment, environmental toxin exposure and climate change influences the risk of disease in later life. The nature of the postnatal environment may interact with the early environment to compound these risks. Recent work has focussed on the effect of maternal obesity.
Specific areas of interest include glucose tolerance, insulin sensitivity, hypothalamo-pituitary-adrenal axis, blood pressure, fat accumulation, neuroinflammation and neuropsychiatric disorders in later life. This research takes an integrative approach, linking whole systems physiology with endocrinological and molecular mechanisms. This work focusses on the effects of environmental toxicant exposure in early life.
Human Development and Health. Human Development and Physiology. Dr Poore has wide ranging teaching activities and responsibilities across the Faculty of Medicine and in Biological Sciences, including leadership of programmes, years and modules. Our research. Research staff. Sort via: Type or Year. Articles Darraj, H. S Cleal, J. Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep.
Journal of Developmental Origins of Health and Disease8 3 Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast. The Journal of Physiology20 Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep. Do not turn to the hypothalamus for feedback on stress if you are growth restricted. Endocrinology7 Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain, Behavior and Immunity25 2 Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep.
Journal of Physiology12 Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Experimental Physiology94 9 Mismatched pre- and postnatal nutrition le to cardiovascular dysfunction and altered renal function in adulthood. Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep.
The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. Pediatric Research62 4 Elmes, M. Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology2 Insulin sensitivity in juvenile and adult large white pigs of low and high birthweight.
Diabetologia47 2 The effects of birth weight and postnatal growth patterns on fat depth and plasma leptin concentrations in juvenile and adult pigs. Journal of Physiology1 Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestation. Journal of Physiology3 The effect of birth weight on hypothalamo-pituitary-adrenal axis function in juvenile and adult pigs. The effect of birth weight on glucose tolerance in pigs at 3 and 12 months of age.
Diabetologia45 9 The effects of birth weight on basal cardiovascular function in pigs at 3 months of age.
Ontogeny of pulmonary and renal angiotensin-converting enzyme in pigs. Molecular and Cellular Endocrinology, The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus. Journal of Endocrinology3 Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist.
American Journal of Obstetrics and Gynecology3 Adrenal responsiveness and the timing of parturition in hypothalamo-pituitary disconnected ovine foetuses with and without constant adrenocorticotrophin infusion. Journal of Neuroendocrinology11 5 Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep. American Journal of Obstetrics and Gynecology5 Angiotensin II infusion in vivo does not modulate cortisol secretion in the late-gestation ovine fetus. Poore, K. Studies on the role of ACTH in the regulation of adrenal responsiveness and the timing of parturition in the ovine fetus.
Journal of Endocrinology2 Conferences Poore, K. Maternal and postweaning obesity alters regulation of the hypothalamo-pituitary adrenal axis in mature adult mice. The role of adrenal morphology in high fat diet-induced anxiety in mature adult mice. Jones, L. Sex-specific effects of prenatal and post-weaning high fat diet on adult mouse offspring skeletal muscle contraction.
Early-life undernutrition induces sex-specific effects on the sympatho-adrenal response to stress in sheep. The effect of growth in early life on metabolic homeostasis in later life. Wilsher, J. Allen Eds. Havemeyer Foundation Monograph Series; No. Hypothalamo-pituitary-adrenal axis responsiveness in adult sheep following early life nutrient restriction. Early Human Development82 8pp. Sex and twinning influence early gestation undernutrition effects on sheep offspring growth. Early Human Development82 8p. Avoidable early life environmental exposures.
The Lancet Planetary Health1 5e—e Review Lewis, R. The role of the placenta in the developmental origins of health and disease: implications for practice. Reviews in Gynaecology and Perinatal Practice6 1 Lecturer to undergraduate medical students on the physiology of reproduction, fetal development, birth and lactation. BSc Biomedical Science. Laboratory-based project supervisor over many years. MSc Dissertation. Project supervision.Meet for sex to southampton
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